Effects of 8-OH-DPAT on motor activity in the rat
作者： Viveka Hillegaart , Marie-Louise Wadenberg , Sven Ahlenius
DOI: 10.1016/0091-3057(89)90036-1
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摘要: Abstract The administration of 8-OH-DPAT to rats produced a dose-dependent suppression spontaneous locomotor activity in an open field arena. was administered the dose range 12.5–1,600 μg·kg −1 SC. Vertical (“rearing”) more sensitive treatment than horizontal (“locomotion”), both terms potency and efficacy. along walls arena (“peripheral activity”) increased, rearing decreased, relative total activity, respectively. There were no effects by on treadmill locomotion. rectal temperature decreased administration, not only animals tested field, but also with increased body temperature,
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