High glucose activates PKC-ζ and NADPH oxidase through autocrine TGF-β1 signaling in mesangial cells

作者: Ling Xia , Hong Wang , Snezana Munk , Janice Kwan , Howard J. Goldberg

DOI: 10.1152/AJPRENAL.00043.2008

关键词:

摘要: Conversion of normally quiescent mesangial cells into extracellular matrix-overproducing myofibroblasts in response to high ambient glucose and transforming growth factor (TGF)-β1 is central the...

参考文章(74)
Alexandre Fontayne, Pham My-Chan Dang, Marie-Anne Gougerot-Pocidalo, Jamel El Benna, Phosphorylation of p47phox sites by PKC alpha, beta II, delta, and zeta: effect on binding to p22phox and on NADPH oxidase activation. Biochemistry. ,vol. 41, pp. 7743- 7750 ,(2002) , 10.1021/BI011953S
Takeshi Nishikawa, Diane Edelstein, Xue Liang Du, Sho-ichi Yamagishi, Takeshi Matsumura, Yasufumi Kaneda, Mark A. Yorek, David Beebe, Peter J. Oates, Hans-Peter Hammes, Ida Giardino, Michael Brownlee, Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage Nature. ,vol. 404, pp. 787- 790 ,(2000) , 10.1038/35008121
T. Hirai, Protein Kinase Cζ (PKCζ) : Activation Mechanisms and Cellular Functions Journal of Biochemistry. ,vol. 133, pp. 1- 7 ,(2003) , 10.1093/JB/MVG017
J W Parce, M C Seeds, D A Bass, P Szejda, M Thomas, L R Dechatelet, Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation. Journal of Immunology. ,vol. 130, pp. 1910- 1917 ,(1983)
Guanghu Wang, Jeane Silva, Kannan Krishnamurthy, Eric Tran, Brian G. Condie, Erhard Bieberich, Direct Binding to Ceramide Activates Protein Kinase Cζ before the Formation of a Pro-apoptotic Complex with PAR-4 in Differentiating Stem Cells Journal of Biological Chemistry. ,vol. 280, pp. 26415- 26424 ,(2005) , 10.1074/JBC.M501492200
Mary L. Standaert, Lamar Galloway, Purushotham Karnam, Gautam Bandyopadhyay, Jorge Moscat, Robert V. Farese, Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport. Journal of Biological Chemistry. ,vol. 272, pp. 30075- 30082 ,(1997) , 10.1074/JBC.272.48.30075
Emiko Manabe, Osamu Handa, Yuji Naito, Katsura Mizushima, Satomi Akagiri, Satoko Adachi, Tomohisa Takagi, Satoshi Kokura, Takashi Maoka, Toshikazu Yoshikawa, Astaxanthin protects mesangial cells from hyperglycemia-induced oxidative signaling† Journal of Cellular Biochemistry. ,vol. 103, pp. 1925- 1937 ,(2008) , 10.1002/JCB.21583