Increased plasma endothelin concentration in atherosclerotic renovascular hypertension.

摘要: The aim was to investigate circulating levels of immunoreactive endothelin (ir-ET) in atherosclerotic renovascular hypertension (RVH), and assess the role kidneys its overall plasma concentration. We studied 16 hypertensive patients with renal artery stenosis evidenced by angiography admitted hospital for diagnostic evaluation RVH vein renin activity (PRA) determinations. right femoral catheter-ized simultaneously measure PRA ir-ET both veins inferior vena cava below origin veins. present 9 as indicated ratios remaining 7 were considered have essential (EH). Patients showed a marked increase systemic concentration (10.3 ± 0.9 pg/ml) compared hypertensives without (6.2 0.6 pg/ml, p