Self‐Assembly of a Guanosine Derivative To Form Nanostructures and Transmembrane Channels

作者: Rabindra Nath Das , Y. Pavan Kumar , S. Arun Kumar , Ole Mathis Schütte , Claudia Steinem

DOI: 10.1002/CHEM.201800205

关键词:

摘要: We herein report the self-assembly of a lipophilic bromoguanosine derivative (G1) in homogeneous solution, solid state and planar bilayer membranes. The G1, driven by H-bonding π-π stacking interactions can form different nano-structures depending on incubation time. G1 nanostructure is able to bind bioactive dye like Rose Bengal. In crystal state, it shows ribbon type pattern exhibits birefringence polarized light. And further, self-assembled discrete transmembrane ion channels lipid membranes, enabling passage potassium ions.

参考文章(60)
C. R. Martin, Z. S. Siwy, Learning Nature's Way: Biosensing with Synthetic Nanopores Science. ,vol. 317, pp. 331- 332 ,(2007) , 10.1126/SCIENCE.1146126
Maki Koike-Tani, Tomomi Tani, Shalin B. Mehta, Amitabh Verma, Rudolf Oldenbourg, Polarized light microscopy in reproductive and developmental biology. Molecular Reproduction and Development. ,vol. 82, pp. 548- 562 ,(2015) , 10.1002/MRD.22221
Giovanni Gottarelli, Stefano Masiero, Elisabetta Mezzina, Silvia Pieraccini, Jürgen P. Rabe, Paolo Samorí, Gian Piero Spada, The Self-Assembly of Lipophilic Guanosine Derivatives in Solution and on Solid Surfaces Chemistry - A European Journal. ,vol. 6, pp. 3242- 3248 ,(2000) , 10.1002/1521-3765(20000901)6:17<3242::AID-CHEM3242>3.0.CO;2-K
Jonathan L. Sessler, Muhunthan Sathiosatham, Katherine Doerr, Vincent Lynch, Khalil A. Abboud, A G-Quartet Formed in the Absence of a Templating Metal Cation: A New 8-(N,N-dimethylaniline)guanosine Derivative Angewandte Chemie International Edition. ,vol. 39, pp. 1300- 1303 ,(2000) , 10.1002/(SICI)1521-3773(20000403)39:7<1300::AID-ANIE1300>3.0.CO;2-I
Szilard N. Fejer, Dwaipayan Chakrabarti, David J. Wales, Self-assembly of anisotropic particles Soft Matter. ,vol. 7, pp. 3553- 3564 ,(2011) , 10.1039/C0SM01289K
Jyotirmayee Dash, Avinash J. Patil, Rabindra Nath Das, Fern L. Dowdall, Stephen Mann, Supramolecular hydrogels derived from silver ion-mediated self-assembly of 5′-guanosine monophosphate Soft Matter. ,vol. 7, pp. 8120- 8126 ,(2011) , 10.1039/C1SM05839H
Lauren E. Buerkle, Horst A. von Recum, Stuart J. Rowan, Toward potential supramolecular tissue engineering scaffolds based on guanosine derivatives Chemical Science. ,vol. 3, pp. 564- 572 ,(2012) , 10.1039/C1SC00729G
Stefano Lena, Stefano Masiero, Silvia Pieraccini, Gian Piero Spada, Guanosine Hydrogen‐Bonded Scaffolds: A New Way to Control the Bottom‐Up Realisation of Well‐Defined Nanoarchitectures Chemistry: A European Journal. ,vol. 15, pp. 7792- 7806 ,(2009) , 10.1002/CHEM.200802506
Paul H. Schlesinger, Riccardo Ferdani, Jun Liu, Jolanta Pajewska, Robert Pajewski, Mitsuyoshi Saito, Hossein Shabany, George W. Gokel, SCMTR: A Chloride-Selective, Membrane-Anchored Peptide Channel that Exhibits Voltage Gating Journal of the American Chemical Society. ,vol. 124, pp. 1848- 1849 ,(2002) , 10.1021/JA016784D
Mark S. Kaucher, William A. Harrell, Jeffery T. Davis, A Unimolecular G-Quadruplex that Functions as a Synthetic Transmembrane Na+ Transporter Journal of the American Chemical Society. ,vol. 128, pp. 38- 39 ,(2006) , 10.1021/JA056888E