Mechanisms of action of novel skin penetration enhancers: phospholipid versus skin lipid liposomes.

作者: Gamal M.M. El Maghraby , Michael Campbell , Barrie C. Finnin

DOI: 10.1016/J.IJPHARM.2005.08.016

关键词:

摘要: Employing thermal analysis, we investigated the mechanism of action novel enhancers and probed phospholipid (PL) versus stratum corneum lipid (SCL) liposomes as model membranes. The included octyl salicylate (OS), padimate O (PADO) 2-(1-nonyl)-1,3-dioxolane (ND). negative controls were empty liposomes. Positive employed dimethylsulfoxide (DMSO) Azone (AZ). For PL liposomes, DMSO sharpened transitions. AZ abolished pre-transition, broadened main transition linearly reduced its temperature (T(m)). OS or PADO T(m) size decreased (non-linearly). ND pre-transition but increased endotherm, suggesting retardation rather than enhancement. results SCL correlated with except for ND. In peaks indicating disruption, which indicated enhancing effects. conclusion, OS, can enhance drugs by disrupting intercellular domain they differ from in terms relationship between efficacy concentration. Although are simple membranes sharp transitions give detailed information about effects enhancers, provide misleading results. Simultaneous use other models like is recommended.

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