Pressure-Volume Relations

摘要: The physiologic characterization of an intact ventricular chamber ideally employs analyses yielding integrated functional assessments as well separate quantification the major factors (i.e. load, contractility, diastolic function) that determine net performance. More than a century ago, Otto Frank initiated studies to assess function by relations between pressure and volume, approach already familiar 19’ engineers. In one diagram, both active passive filling properties pump, its mechano-energetics, interaction with vascular loading systems could all be quantified. pioneering work Suga, Sagawa colleagues in 1970’s, performed isolated yet physiologically ejecting canine ventricles (1), established pressure-volume relationship powerful means achieve goals analysis. Beyond utility end-systolic load-independent index analysis proved insightful valuable laboratory research clinical (2-3). Recently, this method has been extended miniaturized catheter technology mouse (4). capacity genetically alter mice combined in-depth hemodynamic in-vivo presents unparalleled potential for interfacing molecular science cardiac physiology. This chapter reviews instrumentation methods involved vivo relation measurement mice. Cardiovascular physiology normal are compared published reference human data, examples from transgenic models shown highlight method.