Potential application of liposomal nanodevices for non-cancer diseases: an update on design, characterization and biopharmaceutical evaluation

摘要: Liposomes, lipid-based vesicular systems, have attracted major interest as a means to improve drug delivery various organs and tissues in the human body. Recent literature highlights benefits of liposomes for use including encapsulating both hydrophobic hydrophilic cargos, passive active targeting, enhanced bioavailability therapeutic effects, reduced systemic side improved cargo penetration into target tissue triggered contents release. Pioneering work researchers led introduction long-circulating, ligand-targeted release liposomes, well as, containing nucleic acids vesicles combination cargos. Altogether, these findings widespread application plethora areas from cancer conditions such cardiovascular, neurologic, respiratory, skin, autoimmune eye disorders. There are numerous review articles on treatment cancer, which seems primary focus, whereas other diseases also benefit liposome-mediated treatments. Therefore, this article provides an illustrated detailed overview liposomal formulations, vitro characterization their applications different disorders than cancer. Challenges future directions, must be considered obtain most disorders, discussed.