Testing predictors of bipolar-II disorder with a 2-day minimum duration of hypomania.

摘要: The study's aim was to find if features often reported distinguish bipolar and depressive disorders could predict bipolar-II disorder (BP-II). Consecutive major episode (MDE) outpatients, including 284 with BP-II 196 (MDD), were interviewed the Structured Clinical Interview for DSM-IV, Hypomania Guide, Family History Screen, in a private practice. minimum duration of past hypomania 2 days. Mixed depression defined as an MDE plus three or more intradepressive, non-euphoric hypomanic symptoms. predictors early onset ( 4 MDEs), family history, mixed depression, atypical depressions. Bipolar history had highest positive predictive value (PPV) (80.8%) but low sample frequency (32.7%); high PPV (75.2%) 37.0%; many recurrences (70.4%) lowest (66.5%). Combinations (79.0%) 46.6%. Predictors combinations may correctly identify 75% 80% BP-II, reducing misdiagnosis MDD (by prompting careful probing history), improving treatment (as antidepressants alone worsen course). As is related disease prevalence, findings need be replicated different settings.