Benzimidazole-core as an antimycobacterial agent.

摘要: Mycobacterium tuberculosis (Mtb) is considered as one of the precarious bacterial infections around world. Through a projected 8.7 million new (TB) cases and 1.4 mortalities per annum, this deadly infection resulted insubstantial amount human deaths than any other single organism infections. TB India’s most threatening health problems it accounts for approximately 33% global issues. Subsequently, there an imperative need improvement existing drug candidates with newer targets specified mechanism action. Within wide spectra heterocycles, benzimidazole its substituted analogues were evidenced promising biological efficacies enabling them to perform or prodrug candidates. Exceptional structural features class heterocycle versatile applications made privileged backbone in design discovery. Majorly, 2,5- 2,6-disubstituted derivatives shown induce significant antiTB potential. To seek more insights on unique feature candidates, urgency assemble recent advances area. This review presents overview advancements focuses responsible compiled published reports emphasizing different approaches employed their syntheses order help medicinal clinical chemists designing next generation, yet effective safer