The alpha2-delta protein: an auxiliary subunit of voltage-dependent calcium channels as a recognized drug target.
作者： James Offord , Andrew J Thorpe
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摘要: Currently, there are two drugs on the market, gabapentin (Neurontin) and pregabalin (Lyrica), that proposed to exert their therapeutic effect through binding alpha2-delta subunit of voltage-sensitive calcium channels. This activity was unexpected, as had previously been considered not be a pharmacological target. In this review, role subunits is discussed mechanism action ligands in vitro vivo summarized. Finally, new insights into bind protein discussed.
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