Modifications of the notch function by Abruptex mutations in Drosophila melanogaster.

摘要: The function of the Notch gene is required in cell interactions defining alternative fates several developmental processes. encodes a transmembrane protein with 36 epidermal growth factor (EGF)-like repeats its extracellular domain. This functions as receptor that interacts other proteins, such Serrate and Delta, which also have EGF their Abruptex mutations locus are associated amino acid substitutions 24-29 protein. We studied, genetic combinations, modifications caused by mutations. These lead to phenotypes opposite those deletions. modified presence loci, particular genes Delta well Hairless, groucho. results suggest all cause stronger than normal activation Some alleles display an insufficiency N function. produce enhancement insufficiency. could be due reduced ability proteins interact ligands and/or form functional dimers.