Alzheimer's Disease: Mechanism and Approach to Cell Therapy

摘要: Alzheimer's disease (AD) is the most common form of dementia. The risk AD increases with age. Although two main pathological features AD, amyloid plaques and neurofibrillary tangles, were already recognized by Alois Alzheimer at beginning 20th century, pathogenesis remains unsettled. Therapeutic approaches targeting or tangles have not yet resulted in satisfactory improvements treatment. This may, part, be due to early-onset late-onset being underpinned different mechanisms. Most animal models are generated from gene mutations involved early onset familial accounting for only 1% all cases, which may consequently complicate our understanding In this article, authors discuss according neuropathologies, including senescence-related mechanisms possible treatments using stem cells, namely mesenchymal neural cells.