Cellular Signaling Events in B Lymphocytes

摘要: The B lymphocyte is the principal cellular mediator of specific humoral immune response to infection. cells arise from pluripotent stem in bone marrow via a number well-defined precursor B-cell phenotypes complex process that integrates signals generated by immunoregulatory receptors on several cell types, often specialized environments (Cushley and Harnett, 1993). Once emerge into periphery, selection appropriate clones antigen can lead (1) anergy and/ or apoptosis immature cells, (2) activation proliferation mature (3) rescue germinal center suicide followed differentiation antibody-secreting plasma memory (reviewed Cushley mechanism which (mlg) elicit these different biological responses maturation-state-dependent manner one central problems yet be resolved. However, it clear many signaling events involved are regulated both cytokines O’Garra et al., 1988) membrane-associated ligands helper T Clark Lane, 1991). Characterization has unifying model (interacting) coreceptor complexes (e.g., CD19/CD21, CD22, CD38, CD40) cytokine IL-4R) modulate mIg-mediated 1994).