Formulações de anestésicos locais de liberação controlada: aplicações terapêuticas

摘要: BACKGROUND AND OBJECTIVES: Many researchers in the last four decades have been devoted to development of drug-delivery systems. Since its first application pharmaceutical industry, many results obtained especially molecular manipulation carriers and their interaction with encapsulated drugs. These new advantage bypassing drugs restraining physicochemical properties (such as water or membrane solubility), thus improving pharmacodynamics (therapeutic effect potentiation), pharmacokinetics (control tissue absorption distribution) toxic effects (lower local systemic toxicity). Liposomes cyclodextrins are among most important which shown be quite advantageous systems for anesthetics. This study aimed at reviewing anesthetics liposomes cyclodextrins, basic applied research on field, addition therapeutic applicability these formulations. CONTENTS: ability control drug delivery target tissues, fractionating release site action. Cyclodextrins, other hand, change intensity duration due low absorption. Basic clinical studies pointed out that administration liposome cyclodextrin formulations induces slow drugs, prolonging anesthetic action decreasing cardiac nervous toxicity. CONCLUSIONS: Although still progress, flagging a direction safer more effective