Physiologic effects of anesthesia induced and maintained by intravenous administration of a climazolam-ketamine combination in ponies premedicated with acepromazine and xylazine.

摘要: OBJECTIVE To examine the physiologic and pharmacokinetic effects of a technique total intravenous anesthesia in ponies. ANIMALS 6 healthy PROCEDURE Ponies were premedicated with acepromazine (0.03 mg/kg body weight, IV) xylazine (1.0 mg/kg, IV). Two minutes later, was induced ketamine (2.0 followed by climazolam (0.2 Anesthesia maintained for 120 an infusion (0.4 mg/kg/h) (6.0 mg/kg/h). Oxygen (5 L/min) supplemented. 20 after stopped sarmazenil (0.04 administered. Cardiovascular respiratory function measurements taken before premedication, during anesthesia. Plasma cortsol, ACTH, catecholamine concentrations used to assess adrenal pituitary gland Ketamine kinetics calculated, on basis plasma drug concentrations. RESULTS There no significant changes from pre-xylazine values heart rate, arterial blood pressure, cardiac index, systemic vascular resistance, or PO2, PCO2, pH. cortisol concentration decreased anesthesia, but ACTH did not change. Recovery fairly smooth, some excitement ataxia noted 2 CONCLUSION Ketamine-climazolan appeared suitable maintenance ponies, although recovery ideal