Cyclic derivatives as modulators of chemokine receptor activity
作者： Robert J. Cherney
DOI:
关键词:
摘要: The present application describes modulators of MCP-1 formula (I): or pharmaceutically acceptable salt forms thereof, useful for the treatment rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma.
lens.org参考文章(222)
Rosalba Salcedo, Maria Lourdes Ponce, Howard A. Young, Ken Wasserman, Jerrold M. Ward, Hynda K. Kleinman, Joost J. Oppenheim, William J. Murphy, Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression. Blood. ,vol. 96, pp. 34- 40 ,(2000) , 10.1182/BLOOD.V96.1.34
Stefanie Gaupp, David Pitt, William A. Kuziel, Barbara Cannella, Cedric S. Raine, Experimental autoimmune encephalomyelitis (EAE) in CCR2(-/-) mice: susceptibility in multiple strains. American Journal of Pathology. ,vol. 162, pp. 139- 150 ,(2003) , 10.1016/S0002-9440(10)63805-9
Albert Zlotnik, Osamu Yoshie, Chemokines: A New Classification System and Their Role in Immunity Immunity. ,vol. 12, pp. 121- 127 ,(2000) , 10.1016/S1074-7613(00)80165-X
Alfredo Garzino-Demo, Methods for treating hiv-associated dementia ,(1999)
Adalbert Braig, Sonia Megert, Kazuhiko Kunimoto, Junji Otani, Patrick Verhoustraeten, Hiroshi Yamamoto, Kunihiko Kodama, Fluorescent maleimides and uses thereof ,(2000)
Alessandra Zingoni, Clelia T. Storlazzi, Gaia Spinetti, Angela Santoni, Mariano Rocchi, Anna Nista, Monica Napolitano, Giovanni Bernardini, Molecular cloning of TER1, a chemokine receptor-like gene expressed by lymphoid tissues. Journal of Immunology. ,vol. 157, pp. 2759- 2763 ,(1996)
Reza Abdi, Terry K. Means, Toshiro Ito, Rex Neal Smith, Nader Najafian, Mollie Jurewicz, Vaja Tchipachvili, Israel Charo, Hugh Auchincloss, Mohamed H. Sayegh, Andrew D. Luster, Differential role of CCR2 in islet and heart allograft rejection: tissue specificity of chemokine/chemokine receptor function in vivo. Journal of Immunology. ,vol. 172, pp. 767- 775 ,(2004) , 10.4049/JIMMUNOL.172.2.767
Nicholas Kindor, Richard Evans, Stephen Thom, Brian Springthorpe, David Harden, David Marriott, Matthew Perry, Andrew Baxter, Thomas McInally, Substituted piperidine compounds useful as modulators of chemokine receptor activity ,(2000)
David Rasnick, Jeffrey Lee Klaus, James T. Palmer, Elaine Yee-Lin Kuo, Reversible cysteine protease inhibitors ,(1996)
Heinz W. Pauls, Michael R. Myers, John Z. Jiang, Wan F. Lau, Alfred P. Spada, Yong Mi Choi-Sledeski, Barbara A. Hanney, Michael R. Becker, Stephen M. Condon, Roderick S. Davis, William R. Ewing, Gregory B. Poli, Wei He, Christopher J. Burns, Aiwen Li, SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS ,(1999)