A novel approach to enhance the mucoadhesion of lipid drug nanocarriers for improved drug delivery to the buccal mucosa
作者： Joanne D. Du , Qingtao Liu , Stefan Salentinig , Tri-Hung Nguyen , Ben J. Boyd
DOI: 10.1016/J.IJPHARM.2014.05.044
关键词:
摘要: Abstract Targeted drug delivery to the buccal mucosa offers distinct advantages over oral gastrointestinal tract including by-passing hepatic first-pass metabolism. However, route is often limited by low bioavailability, loading and reduced residence time due salivary excretion clearance. To overcome these limitations, a novel mucoadhesive formulation based on liquid crystalline nanoparticles was designed. Utilising pH induced in situ transition from stable vesicle dispersed inverse hexagonal phase (hexosomes) enhanced adsorption onto mucosal surface enabled. Firstly, behaviour of amphiphilic lipid phytantriol (PHY) oleic acid (OA) assessed 2–9 using small-angle X-ray scattering (SAXS) cryo-transmission electron microscopy (cryo-TEM) determine appropriate composition for hexosome transition. The colloidal stability determined turbidity studies. Dispersions comprising 30% w/w OA PHY were able form vesicles at 8 hexosomes when exposed pH ex vivo studies utilising excised porcine tissue indicated significant retention -formed PHY/OA compared control DOPC ( p transformation has been identified with potential enhance surfaces.
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