Expression of BRCA1 and BRCA2 in normal and neoplastic cells.
作者： Lewis A. Chodosh
关键词:
摘要: Current evidence strongly supports a role forthe breast cancer susceptibility genes, BRCA1 and BRCA2, in both normal development carcinogenesis.Valuable clues regarding the function of these genes have been garnered through studies theirpatterns expression. A central feature vivopattern BRCA2 expression is that each ofthese putative tumor suppressor expressed at maximal levels rapidly proliferatingcells. This consistent with vitroobservations are acell cycle-dependent manner. also wellillustrated during mammary gland wherein theexpression induced rapidlyproliferating cellular compartments undergoingdifferentiation, such as terminal end buds duringpuberty developing alveoli pregnancy.Strikingly, spatial temporal patterns BRCA1and virtually indistinguishableduring embryonic multiple adulttissues despite fact areunrelated. These observations contributed to theemerging hypothesis similarregulatory pathways.
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