Cholinergic and perfusion brain networks in Parkinson disease dementia
作者： Sean J. Colloby , Ian G. McKeith , David J. Burn , David J. Wyper , John T. O'Brien
DOI: 10.1212/WNL.0000000000002839
关键词:
摘要: Objective: To investigate muscarinic M1/M4 cholinergic networks in Parkinson disease dementia (PDD) and their association with changes Mini-Mental State Examination (MMSE) after 12 weeks of treatment donepezil. Methods: Forty-nine participants (25 PDD 24 elderly controls) underwent 123 I-QNB 99m Tc-exametazime SPECT scanning. We implemented voxel principal components (PC) analysis, producing a series PC images patterns interrelated voxels across individuals. Linear regression analyses derived specific perfusion spatial covariance (SCPs). Results: found an SCP relative decreased binding basal forebrain, temporal, striatum, insula, anterior cingulate ( F 1,47 = 31.9, p 177.5, r 0.58, 0.005) revealed relatively preserved/increased pre/medial/orbitofrontal, parietal, posterior areas coinciding the DMN frontoparietal networks. Conclusion: Dysfunctional limbic-paralimbic salience were associated PDD. Established maintenance may be prerequisite for cognitive remediation following this condition.
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