摘要: Antidepressant pharmacotherapy is to date the most often used treatment for depression, but exact mechanism of action underlying its therapeutic effect still unclear. Many theories have been put forward account as well antidepressant activity, none them exhaustive. Neuroimmune endocrine impairment found in depressed patients; high levels circulating corticosteroids along with hyperactivation immune system, proinflammatory cytokines, low melatonin plasma and urine, disentrainment circadian rhythms demonstrated. Moreover, seems correct or at least interfere these alterations. In this review, we summarize complex neuroimmune chronobiological alterations patients depression how systems interact each other. We also explain therapy can modify systems, some possible mechanisms shown animal human models.
doaj.org参考文章(208)
Saebom Lee, Jaehoon Jeong, Yongdo Kwak, Sang Ki Park, Depression research: where are we now? Molecular Brain. ,vol. 3, pp. 8- 8 ,(2010) , 10.1186/1756-6606-3-8
Carmine M Pariante, Andrew Makoff, Simon Lovestone, Susan Feroli, Alexandra Heyden, Andrew H Miller, Robert W Kerwin, Antidepressants enhance glucocorticoid receptor function in vitro by modulating the membrane steroid transporters. British Journal of Pharmacology. ,vol. 134, pp. 1335- 1343 ,(2001) , 10.1038/SJ.BJP.0704368
Ana García‐Navarro, Cristina González‐Puga, Germaine Escames, Luis C López, Ana López, Manuel López‐Cantarero, Encarnación Camacho, Antonio Espinosa, Miguel Angel Gallo, Darío Acuña‐Castroviejo, None, Cellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture. Journal of Pineal Research. ,vol. 43, pp. 195- 205 ,(2007) , 10.1111/J.1600-079X.2007.00463.X
M. J. Millan, A. Gobert, F. Lejeune, A. Dekeyne, A. Newman-Tancredi, V. Pasteau, J.-M. Rivet, D. Cussac, The Novel Melatonin Agonist Agomelatine (S20098) Is an Antagonist at 5-Hydroxytryptamine2C Receptors, Blockade of Which Enhances the Activity of Frontocortical Dopaminergic and Adrenergic Pathways Journal of Pharmacology and Experimental Therapeutics. ,vol. 306, pp. 954- 964 ,(2003) , 10.1124/JPET.103.051797
Anne Germain, David J. Kupfer, Circadian rhythm disturbances in depression. Human Psychopharmacology-clinical and Experimental. ,vol. 23, pp. 571- 585 ,(2008) , 10.1002/HUP.964
M Germana Orrù, Antonella Baita, Rossella Sitzia, Alessandra Costa, Elisabetta Muntoni, Sabine Landau, Luchino Chessa, M Giulia Farci, Bernardo Carpiniello, Carmine M Pariante, None, [Interferon-alpha-induced psychiatric side effects in patients with chronic viral hepatitis: a prospective, observational, controlled study]. Epidemiologia E Psichiatria Sociale-an International Journal for Epidemiology and Psychiatric Sciences. ,vol. 14, pp. 145- 153 ,(2005) , 10.1017/S1121189X00006394
P. A. C. M. Fernandes, B. Bothorel, D. Clesse, A. W. A. Monteiro, C. Calgari, S. Raison, V. Simonneaux, R. P. Markus, Local corticosterone infusion enhances nocturnal pineal melatonin production in vivo. Journal of Neuroendocrinology. ,vol. 21, pp. 90- 97 ,(2009) , 10.1111/J.1365-2826.2008.01817.X
M. Sanchez-Hidalgo, Z. Lu, D.-X. Tan, M. D. Maldonado, R. J. Reiter, R. I. Gregerman, Melatonin inhibits fatty acid-induced triglyceride accumulation in ROS17/2.8 cells: implications for osteoblast differentiation and osteoporosis American Journal of Physiology-regulatory Integrative and Comparative Physiology. ,vol. 292, ,(2007) , 10.1152/AJPREGU.00013.2007
H. Okamura, Suprachiasmatic nucleus clock time in the mammalian circadian system. Cold Spring Harbor Symposia on Quantitative Biology. ,vol. 72, pp. 551- 556 ,(2007) , 10.1101/SQB.2007.72.033
Tim F. Oberlander, Joanne Weinberg, Michael Papsdorf, Ruth Grunau, Shaila Misri, Angela M. Devlin, Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses Epigenetics. ,vol. 3, pp. 97- 106 ,(2008) , 10.4161/EPI.3.2.6034