A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies.
作者： Lori B. Chibnik , Lori B. Chibnik , Daniel Felsky , Daniel Felsky , Marta Olah
DOI: 10.1038/S41398-020-01175-9
关键词:
摘要: Microglial dysfunction has been proposed as one of the many cellular mechanisms that can contribute to development Alzheimer's disease (AD). Here, using a transcriptional network map human frontal cortex, we identify five modules co-expressed genes related microglia and assess their role in neuropathologic features AD 540 subjects from two cohort studies brain aging. Two these programs-modules 113 114-relate accumulation β-amyloid, while module 5 relates tau pathology. We replicate associations epigenomic data independent datasets. In terms tau, propose 5, marker activated microglia, may lead subsequent cognitive decline. validate our model further by showing three representative (ACADVL, TRABD, VASP) encode proteins are upregulated AD.
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