Chapter 3.2 – Glucocorticoid effects on gene expression
作者： Tomoshige Kino , George P. Chrousos
DOI: 10.1016/S0921-0709(05)80017-3
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摘要: Abstract: Glucocorticoids secreted from the adrenal glands have extremely diverse effects on many physiological functions. They exert most of their actions by changing transcription rates responsive genes through intracellular glucocorticoid receptor (GR). Glucocorticoid-bound GR interacts with specific DNA sequences called response elements located in promoter regions genes, directly stimulating or suppressing transcriptional activities. also indirectly modulates activity numerous factors associating them via mutual protein–protein interactions. Though these mechanisms regulation, glucocorticoids different, distinct cells, tissues and organs, including central nervous, metabolic, musculo-skeletal, connective tissue cardiovascular systems.
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