Analgesic Concentrations of Lidocaine Suppress Tonic A-delta and C Fiber Discharges Produced by Acute Injury

摘要: Intravenous lidocaine has been shown to relieve acute postoperative pain and chronic neuropathic pain. It is not known whether analgesia produced by 2-10 micrograms/ml plasma concentrations of due an effect on peripheral-pain-transducing nerves or central nervous system effects. The current study examined effects analgesic injury-induced discharge A-delta C fibers, using the in vitro rabbit corneal nerve preparation. Lidocaine at from 1-20 reversibly suppressed tonic action potential acutely injured nerves. median effective concentration (ED50) (5.7 micrograms/ml) corresponds clinically for analgesia. Electrically evoked conduction was blocked until were greater than 250 micrograms/ml. Thus, appears result suppression neural peripheral fiber nociceptors.