Chapter Six – A Genomic View of Secondary Metabolite Production in Cyanobacteria

摘要: Abstract Cyanobacteria produce a wide range of secondary metabolites that are very diverse in chemical structure. These show also biological activities, including cytotoxicity, neurotoxicity, dermatotoxicity, and inhibition proteases. The cyanotoxins harmful to animals, humans, essentially produced by freshwater cyanobacteria, while marine terrestrial cyanobacteria some promising new drugs. Between 2001 2010, many biosyntheses cyanobacterial have been deciphered at the genetic biochemical level. Thanks advent genomic data on genomes powerful bioinformatic tools, about 30 clusters genes responsible for production identified. studied in vitro, certain cases. For instance, among cyanotoxins, microcystin, cylindrospermopsin, saxitoxin anatoxin-a elucidated. Almost all products polyketide synthases, nonribosomal peptide synthases or hybrid thereof. However, ribosomal peptides like cyanobactins recent genome mining suggest these more represented than first thought cyanobacteria. This review gives an overview connections between their biosynthetic genes, with emphasis most significant cases sunscreens, alkanes terpenes.