Isocyanates as reagents for enantiomer separation: Application to amino acids, N-methylamino acids and 3-hydroxy acids

摘要: Abstract The formation of N-alkylureido derivatives amino acid esters increases the selectivity a chiral stationary phase towards enantiomers, resulting in complete separation, even for proline and isovaline enantiomers. In reaction isocyanates with N-methylamino acids, N-alkylureido/N-alkylamide are formed one step. similar way, 3-hydroxy acids converted into N-alkylcarbamate/N-alkylamide derivatives. By this procedure, enantiomers were separated on phases first time. order elution was determined optically active reference compounds, obtained by stereoselective reduction 3-keto yeast.