The role of leptospirosis reference laboratories.

摘要: The general goal of reference centres is to support the community, from diagnostic laboratories research institutions, in execution their work by providing strains and reagents giving instructions recommendations individual colleagues national international organisations on a wide variety issues. There are different levels centres, local international, with an increasing package tasks responsibilities. Local might limit activities confirmation applying standard testing, while cover wider range design, validation harmonisation technologies monitoring associated global burden distribution leptospirosis its prevention control health decision makers. This chapter focusses four major pillars constituting addition obvious provision substances, i.e. Research training, Diagnosis, Identification Leptospira Surveillance. Due financial organisational constraints, restricted capacity for basic consequently focus applied into various aspects leptospirosis. They offer either individually or groupwise, that vary novel sophisticated methodologies, depending need requests trainee. Most involved preliminary diagnosis obtained at peripheral levels, such as hospitals other involve design diagnostics, quality assurance. causative (or serovars) key identification infection sources critical surveillance. Hence, also development, application methods required unambiguous characterisation new recognised maintenance integrity strain collections. In line central role, frequently local, and/or surveillance linked advisory role production guidelines. Such usually comprise collation morbidity mortality data, signalling outbreaks investigation risks.