Aberrant mitochondrial DNA, associated fusion transcripts and translation products and hybridization probes therefor

作者: Brian Reguly , Gabriel Dakubo , Ryan Parr , Kerry Robinson , Jennifer Creed

DOI:

关键词:

摘要: The present invention provides novel mitochondrial fusion transcripts, the parent mutated mtDNA molecules, and resulting translation products (proteins) for predicting, diagnosing and/or monitoring cancer. Hybridization probes complementary thereto use in methods of are also provided.

参考文章(50)
E A Schon, A Lombes, R Rizzuto, H Nakase, S DiMauro, C T Moraes, Transcription and translation of deleted mitochondrial genomes in Kearns-Sayre syndrome: implications for pathogenesis. American Journal of Human Genetics. ,vol. 46, pp. 418- 427 ,(1990)
John P Jakupciak, Gabriel D Dakubo, Samantha Maragh, Ryan L Parr, Analysis of potential cancer biomarkers in mitochondrial DNA. Current Opinion in Molecular Therapeutics. ,vol. 8, pp. 500- 506 ,(2006)
Christian Kaltschmidt, D. Poujol, R.A. Rupec, G. Messer, Isolation of a hypoxia-induced cDNA with homology to the mammalian growth-related protein p23. Oncology Research. ,vol. 10, pp. 69- 74 ,(1998)
Brian Reguly, Gabriel D. Dakubo, Ryan L. Parr, Kerry Robinson, Robert Thayer, Jennifer Creed, Andrea Maggrah, 3.4 kb mitochondrial dna deletion for use in the detection of cancer ,(2007)
Mark Birch-Machin, Brian Reguly, Gabriel Dakubo, Ryan Parr, Jennifer Maki, Kerry Robinson, Robert Thayer, Andrea Aguirre, Andrew Harbottle, Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers ,(2006)
Edwin F. Ullman, Moshe Schwarzberg, Fluorescence quenching with immunological pairs in immunoassays ,(1975)
Kenneth E. Rubenstein, Edwin F. Ullman, Enzyme amplification assay ,(1972)
Gerald Leroy Rowley, Henry Kork Tom, Concentrating zone method in heterogeneous immunoassays ,(1981)