Trimethoprim/sulfamethoxazole prophylaxis in neutropenic patients

摘要: Abstract A prospective, randomized study was undertaken in neutropenic patients to evaluate the efficacy of prophylactic trimethoprim/sulfamethoxazole reducing infections and assess effect prophylaxis on bacterial fungal flora. Fifty-five with leukemia, lymphoma, or solid tumors randomly received either one single-strength tablet twice daily no drug for period expected neutropenia. Trimethoprim/ sulfamethoxazole did not significantly reduce mean number febrile days per patient, but decrease documented infections. The control group experienced 28 infections, including 11 bacteremias seven infection-associated deaths; that had two infection-related deaths. Patients treated enteric gram-negative bacillary compared 12 group. Fungal occurred four only patient who trimethoprim/sulfamethoxazole. Surveillance cultures revealed lead colonization trimethoprim/sulfamethoxazole-resistant Enterobacteriaceae, Pseudomonas, fungi. Colonization filamentous fungi common both groups related season year rather than antibiotic therapy. In conclusion, trimethoprim/ reduced infectious episodes without increasing risk