The molecular basis for reactivity of anti-Cw1 and anti-Cw3 alloantisera with HLA-B46 haplotypes.
作者： Jacqueline Zemmour , Jenny E. Gumpert , William H. Hlldebrand , Frances E. Ward , Steven G. E. Marsh
DOI: 10.1111/J.1399-0039.1992.TB01943.X
关键词:
摘要: HLA haplotypes containing the HLA-B46 allele react with both anti-Cw1 and anti-Cw3 alloantisera, a pattern of reactivity defined as Cw11 antigen postulated to involve either distinctive or duplicated HLA-C locus. From serological characterization CIR cells transfected B46 cDNA we now demonstrate that these is solely due molecule not an molecule. Furthermore, isolation mRNA from expressing strongly suggest reactions are directed against product conventional Cw1 allele. The antigenic cross-reactivities B62 Cw3 correlate its chimaeric primary structure, which identical B62, except in alpha 1 helix where it Cw1. distribution genetic linkage indicate recent, Asian origin result gene conversion, involving donor recipient. These results neither corresponds novel nor locus, but combination epitopes contributed by linked alleles. nucleotide sequence previously erroneously attributed distinct demonstrated encode Cw8. Isolation clone this library made cell homozygous for haplotype was probably artefact contamination.
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