Curcumin binds to the α‐helical intermediate and to the amyloid form of prion protein – a new mechanism for the inhibition of PrPSc accumulation
作者： Iva Hafner-Bratkovič , Jernej Gašperšič , Lojze M. Šmid , Mara Bresjanac , Roman Jerala
DOI: 10.1111/J.1471-4159.2007.05105.X
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摘要: … Curcumin binds to the prion fibrils in the left-handed chiral arrangement as determined by circular dichroism. We show that curcumin labels the plaques of the brain sections of variant …
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