Interleukin-12 and infectious diseases: a potential novel therapy.

摘要: Interleukin-12 (IL-12) is emerging as a central component of both innate and acquired immunity. The multiplicity biological activities associated with this cytokine, particularly the stimulation cell-mediated immunity, suggests that it may be crucial in control extracellular intracellular infections. In vitro studies, IL-12 production initiated rapidly after infection variety viral, parasitic, fungal bacterial agents. This induction correlates well reported resistance or susceptibility animals to these Other factors may, however, influence responses vivo, including host genetic make-up, microbial load antagonistic cytokine pathways, notably IL-4 IL-10. some situations, direct immune inappropriate worsen disease, so careful consideration type required response needed before therapy initiated. treatment also useful in...