Correlation of Histopathologic Findings of Non-Graft Threatening Preservation/Reperfusion Injury in Time-Zero Liver Needle Biopsies With Short-Term Post-transplantation Laboratory Alterations

摘要: BACKGROUND: Early post-transplantation alterations in liver tests are caused by a variety of etiologies including rejection, biliary or vascular complications, and preservation/reperfusion injury (PRI). OBJECTIVES: The aim this study was to show the correlation between histopathologic changes PRI early period. MATERIALS AND METHODS: Between April 2013 August 2014, findings protocol, time-zero, Tru-Cut, needle biopsies were evaluated 94 cases cadaveric transplantation. included ballooning degeneration, micro- macro-vesicular steatosis, bilirubinostasis, apoptotic cells, bile plugs neutrophilic infiltration. These compared with (15 days) laboratory findings. RESULTS: Clinico-pathologic evaluation all done assessment time-zero possible causes allograft appraised. In 21 patients, specific cause for found rejection and/or surgical complications. remaining 73 cases, there no supported PRI. We classified as: hepatocellular damage (elevation transaminases lactate dehydrogenase), cholestatic alkaline phosphatase total bilirubin) mixed. Hepatocellular function associated presence marked bodies aggregates time zero biopsies, respectively. On other hand, macrovesicular steatosis dominantly mixed (hepatocellular cholestatic) tests. CONCLUSIONS: Any discrepancy pattern may be considered as warning than