Development and Applications of a Practical Continuous Flow Microwave Cell

摘要: A series of synthetic transformations were successfully and safely scaled up to multigram quantities using focused microwave irradiation with a continuous flow reaction cell that was developed in-house which can be easily adapted commercially available instrumentation. The representative reactions investigated included aromatic nucleophilic substitution (SNAr), esterification, the Suzuki cross-coupling reaction. In general, product yields equivalent or greater than those run under conventional thermal heating conditions.