FBPA PET in boron neutron capture therapy for cancer : prediction of 10B concentration in the tumor and normal tissue in a rat xenograft model

摘要: Background: Boron neutron capture therapy (BNCT) is a molecular radiation treatment based on the 10 B (n, α) 7 Li nuclear reaction in cancer cells, which delivery of by 4-borono-phenylalanine conjugated with fructose (BPA-fr) to cells critical importance. The PET tracer 4-borono-2- 18 F-fluoro-phenylalanine (FBPA) has been used predict accumulation BPA-fr before BNCT. However, because difference chemical structure between and FBPA dose administered (therapeutic dose) (tracer dose), predictive value for tumor normal tissues not yet clearly proven. We conducted this study validate as useful test Methods: RGC-6 rat glioma (1.9× ) were implanted subcutaneously seven male F344 rats. On day 20 after implantation, dynamic scan was performed four rats injection 1 h. Whole-body PET/CT h intravenous solution (30.5±0.7 MBq, 1.69± 1.21 mg/kg). tissue various estimated percentage injected per gram (%ID/g). One hour scan, BPA-fructose (167.32±18.65 mg/kg) intravenously, dissected injection. absolute concentration Bi n autopsied blood measured inductively coupled plasma optical emission spectrometry (ICP-OES). Results: highest determined ICP-OES found kidney (4.34 ± 0.84 %ID/g), followed pancreas (2.73 0.63 (1.44 0.44 %ID/g). A significant positive correlation levels (r = 0.91, p <0.05). Conclusions: can reliably well tissues.