Synthesis and in vitro antitumor activity of novel 2-alkyl-5-methoxycarbonyl-11-methyl-6H-pyrido[4,3-b]carbazol-2-ium and 2-alkylellipticin-2-ium chloride derivatives.
作者： Ryota Mori , Asako Kato , Kousuke Komenoi , Haruaki Kurasaki , Touru Iijima
DOI: 10.1016/J.EJMECH.2014.05.032
关键词:
摘要: Twenty-one types of novel ellipticine derivatives and pyridocarbazoles (5-methoxycarbonyl-11-methyl-6H-pyrido[4,3-b]carbazoles) with a nitrosourea moiety, linked by an oxydiethylene unit at the 2 position, were synthesized, their cytotoxicity against HeLa S-3 cells was evaluated. Some these new compounds exhibited potent antitumor activity comparison that ellipticine.
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