Evidence against ATP being the nonadrenergic, noncholinergic inhibitory transmitter in guinea pig stomach
作者： Robert Frew , Paul M. Lundy
DOI: 10.1016/0014-2999(82)90453-8
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摘要: The adenosine-sensitive P 1 purinoceptor antagonists 8-phenyl theophylline and 8-( p -bromophenyl)theophylline (4 μM) antagonized ATP-induced relaxation of spontaneous tone in guinea pig stomach, but caused no significant modification to electrical field stimulation (0.2–10 Hz, msec for 30 sec, atropine 1.5 μM, guanethidine 4 μM treated). These results suggest that fundic muscle ATP acts via hydrolysis adenosine, with subsequent activation purinoceptors, is not the nonadrenergic, noncholinergic inhibitory transmitter stomach fundus.
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