Carbon 13-labeled urea breath test for the diagnosis of Helicobacter pylori infection in children

摘要: Abstract Helicobacter pylori infection is mainly acquired in childhood, and studies on the epidemiology of this depend availability a noninvasive diagnostic test for use children. The aim study was to determine whether carbon 13–labeled urea breath (UBT) can be used children by evaluating: (1) its sensitivity specificity compared with either culture or both rapid urease histologic examination, (2) meal prolonged fast required, (3) usefulness after treatment H. pylori. Eighty-eight (mean age, 10.6 ± 4.19 years) who were undergoing upper endoscopy studied while fasting, not treatment. Children given 50 mg 13 C-urea if they weighed less than kg 75 more glucose polymer solution 7.5 ml water. Breath samples collected at baseline 15, 30, 45, 60 minutes. In 63 fasting UBT 100% sensitive 97.6% specific 30 minutes cutoff value 3.5 d CO 2 per mil. Nonfasting tests 23 children, performed between 1 hours their usual meal, 91.6% specific. fed directly before UBT, reduced 50%. Thirty optimal sampling time. There significant decrease when obtained 15 minutes, possibly caused interference oral urease-producing organisms. 20 infection. highly diagnosis Neither nor required. (J Pediatr 1997;131:815-20)