A methodology for determining patients' eligibility for clinical trials.

作者: Samson W Tu , Carol A Kemper , Nancy M Lane , Robert W Carlson , Mark A Musen

DOI: 10.1055/S-0038-1634933

关键词:

摘要: The task of determining patients' eligibility for clinical trials is knowledge and data intensive. In this paper, we present a model the determination, describe how computer system can assist researchers in performing that task. Qualitative probabilistic approaches to computing summarizing status potentially eligible patients are described. two compared, synthesis draws on strengths each approach proposed. result applying these techniques database HIV-positive patient cases suggests programs such as one described increase accrual rate into trials. These methods may also be applied from electronic records whether practice guidelines apply particular situations.

参考文章(9)
Lucian L. Leape, Practice guidelines and standards: an overview. QRB - Quality Review Bulletin. ,vol. 16, pp. 42- 49 ,(1990) , 10.1016/S0097-5990(16)30335-9
E. H. Shortliffe, L. M. Fagan, M. A. Musen, R. W. Carlson, S. C. Deresinski, T-HELPER: automated support for community-based clinical research. annual symposium on computer application in medical care. pp. 719- 723 ,(1992)
Joseph F. Collins, William O. Williford, David G. Weiss, Stephen F. Bingham, C. James Klett, Planning patient recruitment: Fantasy and reality Statistics in Medicine. ,vol. 3, pp. 435- 443 ,(1984) , 10.1002/SIM.4780030425
Gregory F. Cooper, The computational complexity of probabilistic inference using bayesian belief networks Artificial Intelligence. ,vol. 42, pp. 393- 405 ,(1990) , 10.1016/0004-3702(90)90060-D
François Herrmann, H Kowaloff, C Rury, C Safran, K Rippel, D Rind, E Caraballo, The development of knowledge-based medical records for clinicians caring for patients with HIV infection pp. 495- 500 ,(1992)
G. William Benedict, LRC Coronary Prevention Trial: Baltimore Clinical Pharmacology & Therapeutics. ,vol. 25, pp. 685- 687 ,(1979) , 10.1002/CPT1979255PART2685
Bradford Rh, Agras Ws, Recruitment: an introduction. Circulation. ,vol. 66, ,(1982)