Pentraxin-3 and endothelial dysfunction.

摘要: Pentraxin 3 (PTX3) is involved in vascular inflammation and endothelial dysfunction through various mechanisms. Until now, most studies confirmed an important link between PTX3 identified several pathogenetic pathways. modulates inflammatory cells, thus stimulating inflammation. Within it decreases nitric oxide (NO) synthesis, inhibits cell proliferation alters their functions. blocks the effect of fibroblast growth factor 2 (FGF2) by making a molecular complex with these molecules inactivating them. However, there are substances like tumor necrosis factor-inducible gene 6 protein (TSG-6) that block PTX3-FGF2 interaction. Interacting P-selectin, promotes response dysfunction. also increases matrix metalloproteinases synthesis directly or blocking NO synthesis. From clinical point view, positively correlates arterial hypertension, flow mediated dilation and, intima media thickness. Therefore, involvement pathogenesis evaluation clear, may become biomarker this direction, but further needed to determine its reliability direction. Last not least, could effective therapeutic target for preventing dysfunction, research needs be conducted.