Validity of transcutaneous PCO2 in monitoring chronic hypoventilation treated with non-invasive ventilation.

摘要: Abstract Background Non-invasive ventilation (NIV) is an efficient treatment for patients with chronic hypercapnic respiratory failure (CRF), but requires regular monitoring to detect both diurnal and nocturnal residual hypercapnia. The present study was designed determine 1) whether transcutaneous PCO 2 (PtcCO ) a valid tool PaCO in this group of patients, 2) if overnight instrumental drift the PtcCO sensor clinically significant. Methods Sixty-seven CRF on long term NIV were included. Arterial blood gases (ABG) sampled from radial artery during measurement. recorded 2 min after ABG sampling. Instrumental tested by measuring gas known CO concentration auto-calibration evening, following morning. Findings values ranged 3·97 kPa 9.0 kPa. Thirty-six (53%) hypercapnic. Correlation between highly significant (r  = 0.9, p  . Limits agreement (d ± 2s) were; −0.32; 0.79 kPa. None paired /PtcCO had difference exceeding 1 kPa. mean 0.14 ± 0.54 kPa/8 h (p = 0.04; 95% CI: 0.01–0.27). Interpretation With device tested, stable under NIV-treatment CRF, accurately reflects can be used monitor without any drift. Trial registration N° NCT01845233.