Bronchial Smooth Muscle Remodeling in Nonsevere Asthma
作者： Pierre-Olivier Girodet , Benoit Allard , Matthieu Thumerel , Hugues Begueret , Isabelle Dupin
DOI: 10.1164/RCCM.201507-1404OC
关键词:
摘要: Rationale: Increased bronchial smooth muscle (BSM) mass is a key feature of airway remodeling that classically distinguishes severe from nonsevere asthma. Proliferation BSM cells involves specific mitochondria-dependent pathway in individuals with However, and mitochondrial biogenesis have not been examined asthma.Objectives: We aimed to assess whether an increase was also implicated asthma its relationship mitochondria clinical outcomes.Methods: enrolled 34 never-smoker subjects In addition, we recruited 56 19 as comparative groups (COBRA cohort [Cohorte Obstruction Bronchique et Asthme; Bronchial Asthma Cohort; sponsored by the French National Institute Health Medical Research, INSERM]). A phenotypic characterization performed using questionnaires, atopy pulmonary function testing, exhaled nitric oxid...
sci-hub.se 参考文章(30)
P.-O. Girodet, A. Ozier, T. Trian, H. Begueret, O. Ousova, J.-M. Vernejoux, P. Chanez, R. Marthan, P. Berger, J. M. Tunon de Lara, Mast cell adhesion to bronchial smooth muscle in asthma specifically depends on CD51 and CD44 variant 6. Allergy. ,vol. 65, pp. 1004- 1012 ,(2010) , 10.1111/J.1398-9995.2009.02308.X
H Begueret, P Berger, J M Vernejoux, L Dubuisson, R Marthan, J M Tunon-de-Lara, Inflammation of bronchial smooth muscle in allergic asthma Thorax. ,vol. 62, pp. 8- 15 ,(2007) , 10.1136/THX.2006.062141
Marta Kaminska, Susan Foley, Karim Maghni, Claudine Storness-Bliss, Harvey Coxson, Heberto Ghezzo, Catherine Lemière, Ronald Olivenstein, Pierre Ernst, Qutayba Hamid, James Martin, Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction Journal of Allergy and Clinical Immunology. ,vol. 124, pp. 45- 51.e4 ,(2009) , 10.1016/J.JACI.2009.03.049
S. S. Sidhu, S. Yuan, A. L. Innes, S. Kerr, P. G. Woodruff, L. Hou, S. J. Muller, J. V. Fahy, Roles of epithelial cell-derived periostin in TGF-β activation, collagen production, and collagen gel elasticity in asthma Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 14170- 14175 ,(2010) , 10.1073/PNAS.1009426107
Gerard Cox, Neil C. Thomson, Adalberto S. Rubin, Robert M. Niven, Paul A. Corris, Hans Christian Siersted, Ronald Olivenstein, Ian D. Pavord, David McCormack, Rekha Chaudhuri, John D. Miller, Michel Laviolette, Asthma control during the year after bronchial thermoplasty The New England Journal of Medicine. ,vol. 356, pp. 1327- 1337 ,(2007) , 10.1056/NEJMOA064707
Thomas B. Martins, Michael E. Bandhauer, Ashley M. Bunker, William L. Roberts, Harry R. Hill, New childhood and adult reference intervals for total IgE. The Journal of Allergy and Clinical Immunology. ,vol. 133, pp. 589- 591 ,(2014) , 10.1016/J.JACI.2013.08.037
BERGER, COMPTON, MOLIMARD, WALLS, N'GUYEN, MARTHAN, TUNON-DE-LARA, Mast cell tryptase as a mediator of hyperresponsiveness in human isolated bronchi. Clinical & Experimental Allergy. ,vol. 29, pp. 804- 812 ,(1999) , 10.1046/J.1365-2222.1999.00580.X
Sally E Wenzel, Asthma phenotypes: the evolution from clinical to molecular approaches Nature Medicine. ,vol. 18, pp. 716- 725 ,(2012) , 10.1038/NM.2678
Carmela Pepe, Susan Foley, Joanne Shannon, Catherine Lemiere, Ron Olivenstein, Pierre Ernst, Mara S. Ludwig, James G. Martin, Qutayba Hamid, Differences in airway remodeling between subjects with severe and moderate asthma. The Journal of Allergy and Clinical Immunology. ,vol. 116, pp. 544- 549 ,(2005) , 10.1016/J.JACI.2005.06.011
Geoffrey L Chupp, Chun Geun Lee, Nizar Jarjour, Yun Michael Shim, Carole T Holm, Susan He, James D Dziura, Jennifer Reed, Anthony J Coyle, Peter Kiener, Mark Cullen, Martine Grandsaigne, Marie-Christine Dombret, Michel Aubier, Marina Pretolani, Jack A Elias, None, A Chitinase-like Protein in the Lung and Circulation of Patients with Severe Asthma The New England Journal of Medicine. ,vol. 357, pp. 2016- 2027 ,(2007) , 10.1056/NEJMOA073600