Type III CRISPR-Cas Systems and the Roles of CRISPR-Cas in Bacterial Virulence

摘要: Type III CRISPR-Cas systems constitute nearly a quarter of all known CRISPR and have been found to reside in both archaea bacteria, including important bacterial pathogens such as staphylococci mycobacteria. By blocking the horizontal transfer bacteriophage conjugative plasmids, not only protect against foreign invaders, but also prevent acquisition virulence factors antibiotic resistance cassettes that are encoded these mobile genetic elements. For this reason, can broad impact on evolution pathogens. This chapter explores in-depth our current understanding molecular mechanisms interference type particular, more generally, existing data supporting role emergence