The anaplastic lymphoma kinase testing conundrum
作者： Esther Conde , Philippe Taniere , Fernando Lopez-Rios
DOI: 10.1586/14737159.2015.997713
关键词:
摘要: Given the excellent results of clinical trials with anaplastic lymphoma kinase (ALK) inhibitors, importance accurately identifying ALK-positive lung carcinoma patients has never been greater. It brings it a pressing need for harmonized development companion diagnostics, economic, scientific and medical reasons. Therefore, is crucial that ALK testing assays become more standardized both in performance (analytical phase) interpretation (post-analytical phase). We find methods currently recommended by College American Pathologists/International Association Study Lung Cancer/Association Molecular Pathology guidelines (FISH Immunohistochemistry) are reasonable approaches primary routine testing, if at least 50 tumor cells scored protocols strictly followed. Moreover, due to high demand study multiple predictive biomarkers on different assay platforms, quick reliable achieve this essential guide tre...
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