Role of the NLRP3 Inflammasome: Insights Into Cancer Hallmarks.

摘要: In response to a variety of stresses, mammalian cells activate the inflammasome for targeted caspase-dependent pyroptosis. The research community has recently begun deduce that activation is instigated by several known oncogenic stresses and metabolic perturbations; nevertheless, role inflammasomes in context cancer biology less understood. manipulating expression inflammasome, researchers have found NLRP3 serves as deterministic player conducting tumor fate decisions. Understanding mechanistic underpinning pro-tumorigenic anti-tumorigenic pathways might elucidate novel therapeutic onco-targets, thereby providing new opportunities manipulate augmenting activity prevent expansion achieve metastatic control. Accordingly, this review aims decode complexity NLRP3, whereby summarizing clustering findings into hallmarks tissue contexts may expedite consensus underscore potential drug translation.