Rhodomentosones A and B: Two Pairs of Enantiomeric Phloroglucinol Trimers from Rhodomyrtus tomentosa and Their Asymmetric Biomimetic Synthesis.
作者： Yao-Lan Li , Chuang-Chuang Li , Wei Tang , Wen-Cai Ye , Ren-Wang Jiang
DOI: 10.1021/ACS.ORGLETT.1C01616
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摘要: Rhodomentosones A and B (1 and 2), two pairs of novel enantiomeric phloroglucinol trimers featuring a unique 6/5/5/6/5/5/6-fused ring system were isolated from Rhodomyrtus tomentosa. Their structures with absolute configurations were elucidated by NMR spectroscopy, X-ray crystallography, and ECD calculation. The bioinspired syntheses of 1 and 2 were achieved in six steps featuring an organocatalytic asymmetric dehydroxylation/Michael addition/Kornblum–DeLaMare rearrangement/ketalization cascade reaction …
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