Growth hormone secretion during sleep

摘要: Plasma growth hormone (GH), insulin, cortisol, and glucose were measured during sleep on 38 nights in eight young adults. Blood was drawn from an indwelling catheter at 30-min intervals; EEG electrooculogram recorded throughout the night. In seven subjects, a plasma GH peak (13-72 mμg/ml) lasting 1.5-3.5 hr appeared with onset of deep sleep. Smaller peaks (6-14 occasionally subsequent phases. Peak secretion delayed if delayed. Subjects who awakened for 2-3 allowed to return exhibited another (14-46 mμg/ml). not correlated changes glucose, cortisol. The effects 6-CNS-active drugs sleep-related investigated. Imipramine (50 mg) completely abolished two four whereas chlorpromazine (30 mg), phenobarbital (97 diphenylhydantoin (90 chlordiazepoxide (20 isocarboxazid did inhibit peaks. Altered hypothalamic activity associated initiation results major unrelated hypoglycemia or cortisol insulin secretion.