The Antimalarial Activity of PL74: A Pyridine-Based Drug Candidate

Bornface Gunsaru, Steven J. Burgess, Westin Morrill, Jane X. Kelly, Shawheen Shomloo, Martin J. Smilkstein, Katherine Liebman, David H. Peyton, Simplified Reversed Chloroquines To Overcome Malaria Resistance to Quinoline-Based Drugs. Antimicrobial Agents and Chemotherapy. ,vol. 61, ,(2017) , 10.1128/AAC.01913-16

Holz Gg, Lipids and the malarial parasite. Bulletin of The World Health Organization. ,vol. 55, pp. 237- 248 ,(1977)

John E. Leffler, Ernest Grunwald, Rates and equilibria of organic reactions as treated by statistical, thermodynamic, and extrathermodynamic methods Published in <b>1963</b> reprint in <b>1989</b> in New York NY) by Dover. ,(1989)

Katherine E. Jackson, Nectarios Klonis, David J. P. Ferguson, Akinola Adisa, Con Dogovski, Leann Tilley, Food vacuole-associated lipid bodies and heterogeneous lipid environments in the malaria parasite, Plasmodium falciparum Molecular Microbiology. ,vol. 54, pp. 109- 122 ,(2004) , 10.1111/J.1365-2958.2004.04284.X

Henri J. Vial, Choukri Ben Mamoun, Plasmodium lipids: metabolism and function. Molecular approaches to malaria. pp. 327- 352 ,(2005) , 10.1128/9781555817558.CH17

Renu Tuteja, Malaria - an overview. FEBS Journal. ,vol. 274, pp. 4670- 4679 ,(2007) , 10.1111/J.1742-4658.2007.05997.X

K. Kirk, H.A. Horner, B.C. Elford, J.C. Ellory, C.I. Newbold, Transport of diverse substrates into malaria-infected erythrocytes via a pathway showing functional characteristics of a chloride channel. Journal of Biological Chemistry. ,vol. 269, pp. 3339- 3347 ,(1994) , 10.1016/S0021-9258(17)41868-0

Noureddine ELABBADI, Marie L. ANCELIN, Henri J. VIAL, Phospholipid metabolism of serine in Plasmodium-infected erythrocytes involves phosphatidylserine and direct serine decarboxylation Biochemical Journal. ,vol. 324, pp. 435- 445 ,(1997) , 10.1042/BJ3240435

S Wein, M Maynadier, Y Bordat, J Perez, S Maheshwari, P Bette‐Bobillo, C Tran Van Ba, D Penarete‐Vargas, L Fraisse, R Cerdan, H Vial, Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidate British Journal of Pharmacology. ,vol. 166, pp. 2263- 2276 ,(2012) , 10.1111/J.1476-5381.2012.01966.X

Steven J. Burgess, Audrey Selzer, Jane Xu Kelly, Martin J. Smilkstein, Michael K. Riscoe, David H. Peyton, A chloroquine-like molecule designed to reverse resistance in Plasmodium falciparum. Journal of Medicinal Chemistry. ,vol. 49, pp. 5623- 5625 ,(2006) , 10.1021/JM060399N