Effects of commercially available soy products on PSA in androgen-deprivation-naïve and castration-resistant prostate cancer.

摘要: OBJECTIVE No standard therapeutic option exists for men with prostate cancer who have failed local therapy, no gross metastatic disease, and whose only manifestation of disease is a rising prostate-specific antigen (PSA) level. Soy products are able to affect PSA kinetics in some cancer, this effect has been attributed the decreased expression androgen receptor other mechanisms. METHODS We treated 10 levels after radical prostatectomy salvage radiotherapy commercially available soy products. Scans revealed disease. Three also had receiving androgen-deprivation therapy (ADT) that were consistent castration-resistant (CR) reported results modality on levels, kinetics, duration response. RESULTS Responses occurred 4 7 (57%) patients ADT-naive 1 3 (33%) CR The median treatment response was 24 months. overall clinical benefit, therefore, noted 5 (50%) patients. Therapy well tolerated. CONCLUSIONS Our findings fairly congruent what described literature use cancer. used show can provide benefit experience suggests supplementation using durable beneficial effects