Bioengineering the Bone Marrow Vascular Niche.
作者： Tomer Itkin , Thomas Bessy , Diana Passaro
DOI: 10.3389/FCELL.2021.645496
关键词:
摘要: The bone marrow (BM) tissue is the main physiological site for adult hematopoiesis. In recent years, cellular and matrix components composing BM have been defined with unprecedent resolution, both at molecular structural levels. With expansion of this knowledge, possibility reproducing a BM-like structure, to ectopically support study hematopoiesis, becomes reality. A number experimental systems implemented displayed feasibility bioengineering tissues, supported by cells mesenchymal origin. Despite being known as an abundant component BM, vasculature has largely disregarded its role in regulating formation, organization determination. Recent reports highlighted crucial vascular endothelial shaping development supporting steady state, emergency malignant pre- postnatally. Herein, we review field BM-tissue particular focus on system implementation integration, starting from describing variety applicable vitro models, ending up vivo preclinical models. Additionally, highlight challenges discuss clinical perspectives terms adoptive transfer vascularized BM-niche grafts patients recovering
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