Cellular Circuits in the Brain and Their Modulation in Acute and Chronic Pain.

摘要: Chronic, pathological pain remains a global health problem and challenge to basic clinical sciences. A major obstacle preventing, treating, or reverting chronic has been that the nature of neural circuits underlying diverse components complex, multidimensional experience is not well understood. Moreover, involves maladaptive plasticity processes, which have decoded mechanistically in terms involvement specific cause-effect relationships. This review aims discuss recent advances our understanding circuit connectivity mammalian brain at level regional contributions cell types acute pain. focus placed on functional dissection sub-neocortical using optogenetics, chemogenetics, imaging technological tools rodent models with view towards decoding sensory, affective, motivational-cognitive dimensions The summarizes breakthroughs insights structure-function properties nociceptive higher order modulatory involved aversion, learning, reward, mood their modulation by endogenous GABAergic inhibition, noradrenergic, cholinergic, dopaminergic, serotonergic, peptidergic pathways. knowledge dynamic regulation via structural will be beneficial designing improving targeted therapies.